.
Functional Group Transformation of Carboxylic acid is listed here for students’ help. This collection helps students in retrosynthesis and synthesis of organic molecules. Passerini multicomponent reaction Isocyanides react with carboxylic acids and carbonyl compounds to provide α-acyloxycarboxamides. Hell-Volhard-Zelinsky reaction Preparation of α-halo carboxylic acids by treating a carboxylic acid with halogen at elevated temperatures in […]
Functional Group Transformation of ENONE is listed here for students’ help. This collection helps students in retrosynthesis and synthesis of organic molecules. Wacker oxidation α,β-unsaturated ketones and esters are oxidized regioselectively to 1,3-Dicarbonyl compounds using catalytic amounts of Na2PdCl4 and TBHP or H2O2 as co-oxidants Stetter reaction The addition of aliphatic and aromatic aldehydes across […]
Ultra violet and visible spectroscopy used to measure the extent of multiple bonds or aromatic conjugation within molecules. This test helps students to revise the concepts of electronic spectroscopy. Challenge Yourself!!! ALL THE BEST!!! Also visit Carbonyl IR spectroscopy Organo-Metallics practice test
Organo-Metallics practice test covers syllabus Organo – Li, Si, Mg, Sn, B, Cu, etc. This test helps the student to predict different transformation reactions involving organometallic reagents. Challenge Yourself!!! ALL THE BEST!!! Also attempt Carbonyl IR spectroscopy Practice
Carbonyl derivatives IR spectroscopy practice problems with a detailed solution. This session helps to analyze students learning achievements. Challenge Yourself!!! ALL THE BEST…
DDQ (2 3-dichloro-5 6-dicyano-1 4-benzoquinone) is highly electron-deficient and readily performs dehydrogenation and cyclization. Also used to bring aromaticity in natural products and insertion of the carbonyl group. The substrate must have allylic and benzylic hydrogens to perform dehydrogenation by DDQ. One equivalent DDQ produces one double bond. Different important applications of DDQ are as […]
This article details the 1H NMR Problem 2 schematic method to interpret organic molecule based on information provided in the problem as follows: Problem An organic compound A (C8H16O2) on treatment with an excess of methyl magnesium chloride generated two alcohols B and C, whereas the reaction of A with LiAlH4 generated only a single […]
Oppenauer oxidation uses metal alkoxides (aluminum isopropoxide) for the oxidation of primary and secondary alcohols with ketones. Ketones act as hydrogen acceptors. This method used in the synthesis of natural products. The reaction conditions are mild, most functional groups are tolerated (alkenes, alkynes, esters, amides, etc.) Isomerization of double bond in oppenauer oxidation, to get […]
Based on symmetry criteria protons are classified into three types using NMR splitting. They are homotopic, enantiotopic and diastereotopic protons. This article details the minute characteristic difference between each type of proton. Homotopic protons Symmetry: Protons interchangeable with Cn Symmetry NMR: both protons are chemically equivalent Replacement: protons attached carbon should be achiral before and […]
1H NMR Interpretation Tricks are useful for organic synthesis structure determination. This article discusses the approach to NMR problems. Problem An organic compound (C7H12O2) exhibited the following data in the 1H NMR spectrum. 7.10 (1H, d t, J 16 and 7.2Hz),5.90 (1H, d t, J 16 and 2 Hz),4.1 (2H, q, J 7.2Hz,)2.10 (2H, m),1.25(3H, […]