Functional Group Transformation of ENONE is listed here for students’ help. This collection helps students in retrosynthesis and synthesis of organic molecules.
α,β-unsaturated ketones and esters are oxidized regioselectively to 1,3-Dicarbonyl compounds using catalytic amounts of Na2PdCl4 and TBHP or H2O2 as co-oxidants
The addition of aliphatic and aromatic aldehydes across activated double bonds (α,β-unsaturated ketones, and esters) in the presence of a nucleophilic catalyst (NaCN, KCN).
Formation of a C-C single bond between the α-position of conjugated carbonyl compounds, such as esters and amides, and carbon electrophiles, such as aldehydes and activated ketones in the presence of a suitable nucleophilic catalyst, particularly a tertiary amine.
The transformation of enones to the corresponding allylic alcohols using the combination of cerium chloride/sodium borohydride is known as the Luche reduction
The arylation of substituted alkenes with aryldiazonium halides in the presence of a metal salt catalyst.
When dimethylsulfoxonium methylide is reacted with α,β-unsaturated carbonyl compounds, a conjugate addition takes place to produce a
cyclopropane as the major product.
Addition of stabilized carbon nucleophiles to activated π-systems
The acid- and base-catalyzed or photochemically-induced migration of alkyl groups in cyclohexadienones
Skraup and Doebner-Miller quinoline synthesis
α,β-unsaturated aldehydes or ketones, and aniline in presence of HCl ZnCl2 give substituted quinoline.