Functional Group Transformation of ENONE is listed here for students’ help. This collection helps students in retrosynthesis and synthesis of organic molecules.

Wacker oxidation

α,β-unsaturated ketones and esters are oxidized regioselectively to 1,3-Dicarbonyl compounds using catalytic amounts of Na2PdCl4 and TBHP or H2O2 as co-oxidants

Stetter reaction

The addition of aliphatic and aromatic aldehydes across activated double bonds (α,β-unsaturated ketones, and esters) in the presence of a nucleophilic catalyst (NaCN, KCN).

Baylis-Hillman reaction

Formation of a C-C single bond between the α-position of conjugated carbonyl compounds, such as esters and amides, and carbon electrophiles, such as aldehydes and activated ketones in the presence of a suitable nucleophilic catalyst, particularly a tertiary amine.

Luche reduction

The transformation of enones to the corresponding allylic alcohols using the combination of cerium chloride/sodium borohydride is known as the Luche reduction

Meerwein arylation

The arylation of substituted alkenes with aryldiazonium halides in the presence of a metal salt catalyst.

Corey-Chaykovsky cyclopropanation

When dimethylsulfoxonium methylide is reacted with α,β-unsaturated carbonyl compounds, a conjugate addition takes place to produce a
cyclopropane as the major product.

Michael addition

Addition of stabilized carbon nucleophiles to activated π-systems

Dienone-Phenol rearrangement

The acid- and base-catalyzed or photochemically-induced migration of alkyl groups in cyclohexadienones

Skraup and Doebner-Miller quinoline synthesis

α,β-unsaturated aldehydes or ketones, and aniline in presence of HCl ZnCl2 give substituted quinoline.

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