Inductive Effect: Execution in Organic Chemistry

This article details what is Inductive Effect and its Execution in Organic Chemistry. what is Inductive Effect? The covalent bond between the two atoms with dissimilar electronegativity, electron pair forming the bond is never shared absolutely equally. But is attracted a little more towards the more electronegative atom. Such a covalent bond is known as […]

Carboxylic acid Functional Group Transformation

Functional Group Transformation of Carboxylic acid is listed here for students’ help. This collection helps students in retrosynthesis and synthesis of organic molecules. Passerini multicomponent reaction Isocyanides react with carboxylic acids and carbonyl compounds to provide α-acyloxycarboxamides. Hell-Volhard-Zelinsky reaction Preparation of α-halo carboxylic acids by treating a carboxylic acid with halogen at elevated temperatures in […]

ENONE Functional Group Transformation

Functional Group Transformation of ENONE is listed here for students’ help. This collection helps students in retrosynthesis and synthesis of organic molecules. Wacker oxidation α,β-unsaturated ketones and esters are oxidized regioselectively to 1,3-Dicarbonyl compounds using catalytic amounts of Na2PdCl4 and TBHP or H2O2 as co-oxidants Stetter reaction The addition of aliphatic and aromatic aldehydes across […]

DDQ: Dehydrogenation and Cyclization

DDQ (2 3-dichloro-5 6-dicyano-1 4-benzoquinone) is highly electron-deficient and readily performs dehydrogenation and cyclization. Also used to bring aromaticity in natural products and insertion of the carbonyl group. The substrate must have allylic and benzylic hydrogens to perform dehydrogenation by DDQ. One equivalent DDQ produces one double bond. Different important applications of DDQ are as […]